The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 1992

Filed:

Feb. 24, 1989
Applicant:
Inventors:

Suong-Hyu Hyon, Uji, JP;

Yoshita Ikada, Uji, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; B01J / ;
U.S. Cl.
CPC ...
424426 ; 42721336 ; 424489 ; 424497 ; 42840224 ; 514963 ;
Abstract

Microspheres comprising polylactic acid and a water soluble physiologically active substance and having a mean particle size of from about 0.01 .mu.m to 300 .mu.m, which show not more than 30% of an eluted amount of said physiologically active substance based on the content of said physiologically active substance in the polylactic acid type microspheres after 24 hours in in vitro elution test in phosphate buffer of pH 7.4 at 37.degree. C., and a process for preparing the same. The polylactic acid type microspheres of this invention is advantageous in that the active substance can be uniformly incorporated into the microspheres without loss of the activity, can gradually release the active substance for a long time of period of more than one week.


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