The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 1992
Filed:
Jun. 22, 1990
Jean-Paul Vevert, Pantin, FR;
Francoise Delevallee, Vincennes, FR;
Rogert Deraedt, Pavillons sous Bois, FR;
Roussel Uclaf, , FR;
Abstract
Novel .omega.-mercaptopropanamides and their homologs of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, alkyl and alkoxy of 1 to 5 carbon atoms, --NO.sub.2 and halogen, n is an integer from 1 to 5, R.sub.2 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms and aryl and aralkyl of 6 to 15 carbon atoms optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.3 is selected from the group consisting of a) hydrogen, b) phenyl optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, halogen, --CF.sub.3, carboxymethyl, alkoxycarbonylmethyl with 1 to 5 alkoxy carbon atoms, aralkoxy of 7 to 15 carbon atoms and ##STR3## and c) a heterocycle selected from the group consisting of thiazolyl, 4,5-dihydro-thiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, benzimidazolyl, benzothiazolyl and benzoxazolyl, all optionally substituted with alkyl of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their salts with non-taxic, pharmaceutically acceptable acids and bases with the proviso that when R.sub.2 is hydrogen and n is 1, R.sub.3 is not phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 5 carbon atoms and when R.sub.2 is methyl and n is 1, R.sub.3 is not phenyl substituted with carboxymethyl having very good analgesic activity and enkephalinase inhibiting activity.