The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 1992
Filed:
May. 18, 1990
Shunji Kasai, Osaka, JP;
Ryuji Hiramatsu, Osaka, JP;
Shusei Uno, Osaka, JP;
Masanori Nagai, Osaka, JP;
Hirofumi Arimura, Osaka, JP;
Toshizumi Tanabe, Osaka, JP;
Yasuo Amatsuji, Osaka, JP;
Masaaki Hirose, Osaka, JP;
Masanori Morita, Osaka, JP;
Haruhide Kawabe, Osaka, JP;
The Green Cross Corporation, Osaka, JP;
Abstract
A human prourokinase mutant in which the entire or a partial epidermal growth factor domain of human prourokinase is deleted or a partial epidermal growth factor domain of human prourokinase is replaced by one or more different amino acid residues, said mutant having a longer blood half-life than naturally occurring human prourokinase while retaining prourokinase enzymatic activity. In this human prourokinase mutant the region selected from the group consisting of: (a) from asparagine (10) to cysteine (42); (b) from asparagine (10) to aspartic acid (45); and (c) from asparagine (10) to threonine (49) is missing.