The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 1992
Filed:
Dec. 18, 1990
Masaaki Wakita, Tokyo, JP;
Takashi Tomoda, Tokyo, JP;
Masato Yamaguchi, Tokyo, JP;
Isao Joko, Tokyo, JP;
Hiroshi Morita, Tokyo, JP;
Tetsuro Yamamoto, Kumamoto, JP;
Yoshiaki Motozato, Kumamoto, JP;
Kurita Water Industries Ltd., Tokyo, JP;
Abstract
The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity for the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the separation material with respect to pores having diameters of at least 0.1 .mu.m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.1.sup.6 as determined with polyethylene glycol. The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.10.sup.6 to activation by 1,1'-carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using the corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exhibit after being linked as ligand on the porous particulate material, an affinity to the blood coagulation factor to be covered, so as to form a porous matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 .mu.m.