The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 1992

Filed:

Sep. 23, 1988
Applicant:
Inventors:

Alan D Bennett, Berkshire, GB;

Stephen K Rhind, Berkshire, GB;

Peter A Lowe, Berkshire, GB;

Christopher C Hentschel, London, GB;

Assignee:

Celltech, Ltd., Berkshire, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C12P / ; C12P / ;
U.S. Cl.
CPC ...
435 694 ; 435 691 ; 43525233 ; 4353201 ; 536 27 ; 935 47 ; 935 48 ; 935 49 ; 935 51 ;
Abstract

A process for the production of a fusion protein comprising an active portion of a chloramphenicol acetyltransferase (CAT) protein and a polypeptide. The fusion protein may be purified using CAT substrate affinity chromatography. The eucaryotic polypeptide may be calcitonin or a dervative thereof such as calcitonin-glycine. Other polypeptides described include enzymes such as chymosin, prochymosin and preprochymosin, hormones such as ACTH, insulins, and growth hormones and antigenic polypetides such as foot and mouth disease virus antigenic polypetide. The fusion protein may be cleaved at a site susceptible to selective enzymic or chemical cleavage to produce free polypeptide. The fusion protein may be used as an immunogen.


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