The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 1992
Filed:
Apr. 13, 1989
James P Albarella, Elkhart, IN (US);
Lloyd A Schick, Bristol, IN (US);
Meitak T Yip, Elkhart, IN (US);
Miles Inc., Elkhart, IN (US);
Abstract
The present invention is directed to the elimination of ascorbic acid interference in assay systems, particularly assay systems based upon oxidase-peroxidase coupled reactions. When ascorbic acid is present in a sample, it can act as a reductant thereby interfering with an assay's reagent system. The present invention eliminates this inteference by quickly oxidizing any ascorbate thereby preventing ascorbate from acting as an unwanted reductant. The ascorbate is oxidized using a dual oxidant system comprising a water soluble polymer bound to Cu.sup.+2 and an organic or inorganic oxidant such as chromate, peroxide, or a N-halo derivative. This invention is surprisingly selective and generally will not itself interfere with the assay's reagent system. Furthermore, the present invention is so fast and efficient that it can be incorporated into a convenient format, such as a conventional 'dip-and-read' reagent test strip system.