The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 1991
Filed:
Apr. 27, 1990
Applicant:
Inventor:
Masami Okabe, Passaic, NJ (US);
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
540471 ; 546 65 ; 546 90 ; 546 98 ; 546 99 ; 546100 ; 546123 ; 546156 ; 540476 ; 540479 ; 540559 ; 540586 ; 540576 ; 540219 ; 540221 ; 540224 ; 544247 ; 544250 ; 544252 ; 544300 ; 544310 ; 544316 ; 544317 ; 544318 ; 544319 ; 544320 ; 544321 ; 544324 ; 544327 ; 544328 ; 544331 ; 544333 ; 544361 ; 544405 ;
Abstract
A novel process and intermediates used therein for linking a cephalosporin compound to a quinolone are disclosed. According to the disclosed process, the 2-carboxylic acid moiety of the cephalosporin compound is treated with an organic base. The resulting salt is then reacted with a quinolone compound which has been activated using a haloformate. The reaction is run in a non-aqueous organic solvent. 4-Dimethylaminopyridine is used to promote the reaction between the cephalosporin salt and the activated quinolone.