The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 22, 1991

Filed:

May. 26, 1988
Applicant:
Inventors:

Alex Bollen, Itterbeek, BE;

Jean Gobert, Brussels, BE;

Ernst Wulfert, Brussels, BE;

Assignee:

UCB, S.A., Brussels, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
435 694 ; 435 691 ; 4353201 ; 435255 ; 435256 ; 4352523 ; 4352402 ; 536 27 ; 935 11 ; 935 13 ; 935 44 ; 935 45 ; 935 39 ;
Abstract

The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.


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