The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 1991
Filed:
Apr. 10, 1990
Abraham Fisher, Holon, IL;
Ishai Karton, Nes Ziona, IL;
Israel Institute for Biological Research, Ness Ziona, IL;
Abstract
The invention relates to novel compounds (I) for treating diseases of the central and peripheral nervous system: ##STR1## including enantiomers, racemates and acid addition and quaternary salts thereof, wherein one of X and Y is O and the other of X and Y is N; Q is (CH.sub.2).sub.n or C(CH.sub.3).sub.2 where n is 1, 2 or 3 and the bridge --Q-- is attached at one end to position 1 and at the other end to position 4 or 5, and R.degree. is hydrogen, methyl or hydroxyl; in the moiety ##STR2## the line connecting Z and Y signifies a double bond when X--Z is O--C--R and Y is N, and a single bond when X--Z is N.dbd.C--R and Y is O; Z is C--R wherein R is selected from hydrogen, NH.sub.2, NH-R' (R'=C.sub.1-6 -alkyl), N(R').sub.2, R', C.sub.2-6 -alkenyl, C.sub.2-6 -alkynyl, C.sub.3-7 -cycloalkyl, R' substituted by hydroxy or by 1-6 halogen atoms, R'O-C.sub.1-6 -alkyl, carboxy-C.sub.1-6 -alkyl, R'OCO-C.sub.1-6 -alkyl, amino-C.sub.1-6 -alkyl, R''NH-C.sub.1-6 -alkyl, (R').sub.2 N-C.sub.1-6 -alkyl, 2-oxo-pyrrolidin-1-ylmethyl, aryl, diarylmethylol, and R' substituted by one or two aryl groups, wherein aryl denotes phenyl optionally substituted by 1-3 halogens, R', R'O and(or) CF.sub.3. Also claimed are compounds wherein the line connecting Z and Y signifies the absence of a bond, X is O, Z is H and Y is NH.sub.2, NO.sub.2 or N.sub.3.