The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 1991
Filed:
Jul. 28, 1989
Applicant:
Inventors:
George R Pettit, Paradise Valley, AZ (US);
Yoshiaki Kamano, Tempe, AZ (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
544230 ;
Abstract
The Indian Ocean (South African) marine worm Cephalodiscus gilchristi (Hemichordata Phylum) has been found to contain a series of unusual disteroidal alkaloids designated the Cephalostatins which demonstrate exceptionally potent lymphocytic leukemia (murine P388) cell line inhibitory activity (to ED.sub.50 10.sup.-9 .mu.g/ml). Two new disteriodal alkaloids bearing aromatic C-rings having ED.sub.50 of 10.sup.-2 and 10.sup.-3 .mu.g/mL were isolated and assigned structures based on rigorous interpretation of two-dimensional 400 MHz.sup.1 H and .sup.13 C-nmr. These substances were denominated Cephalostatin 5 and Cephalostatin 6, respectively.