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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5047420 B1

PDFFull Text
Date of Patent:
Sep. 10, 1991

Filed:

Aug. 21, 1989

1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists

Applicant:
Inventors:

Donald W Graham, Mountainside, NJ (US);

Tesfaye Biftu, Parlin, NJ (US);

John C Chabala, Westfield, NJ (US);

Michael N Chang, Newtown, PA (US);

Yuan-Ching P Chiang, Piscataway, NJ (US);

Kathryn L Thompson, Westfield, NJ (US);

Shu S Yang, Bridgewater, NJ (US);

Assignee:

Merck & Co., Inc., Rahway, NJ (US);

Attorneys:

Panzer; Curtis C.

Pfeiffer; Hesna J.

Primary Examiner:

Richard L Raymond

Assistant Examiner:

Susan P Treanor

Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514484 ; 514487 ; 514490 ; 514520 ; 514522 ; 514524 ; 514525 ; 514530 ; 514562 ; 514563 ; 514570 ; 514571 ; 514574 ; 514595 ; 514602 ; 514603 ; 514618 ; 514619 ; 514621 ; 514622 ; 514640 ; 514647 ; 514684 ; 514719 ; 514720 ; 514734 ; 514751 ; 514764 ; 558406 ; 558408 ; 558409 ; 558412 ; 558413 ; 558415 ; 558418 ; 558419 ; 558420 ; 558422 ; 560 12 ; 560 13 ; 560 18 ; 560 19 ; 560 20 ; 560 21 ; 560 22 ; 560 27 ; 560 31 ; 560 32 ; 562426 ; 562429 ; 562430 ; 562432 ; 562435 ; 562441 ; 562442 ; 562454 ; 562455 ; 562457 ; 564 47 ; 564 80 ; 564 83 ; 564 85 ; 564 86 ; 564 87 ; 564 88 ; 564 89 ; 564152 ; 564153 ; 564154 ; 564155 ; 564156 ; 564162 ; 564164 ; 564167 ; 564168 ; 564253 ; 564256 ; 564347 ; 564353 ; 564354 ; 564440 ; 568 27 ; 568 28 ; 568 29 ; 568 33 ; 568 34 ; 568 36 ; 568 37 ; 568 38 ; 568 39 ; 568 42 ; 568 43 ; 568626 ; 568631 ; 568644 ; 568645 ; 568646 ; 568647 ; 568716 ; 568731 ; 568744 ; 568745 ; 568928 ; 570123 ; 570128 ; 570129 ; 570182 ;
Abstract

Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediate by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.

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