The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 1991

Filed:

May. 11, 1988
Applicant:
Inventor:

Mark D Cochran, Carlsbad, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; G01N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424 89 ; 436518 ; 4351723 ; 435236 ; 935 65 ; 935 81 ;
Abstract

Attenuated pseudorabies viruses are provided which comprise DNA including a sequence essential for replication of the attenuated pseudorabies virus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring pseudorabies virus. The DNA encodes mRNAs which, in an animal infected with the attenuated pseudorabies virus, are translated into antigenic pseudorabies virus gene products which invoke in the infected animal an immunological response distinguishable from an immunological response invoked in an animal infected with a naturally-occurring pseudorabies virus. Also provided are vaccines which comprise the attenuated pseudorabies virus of the present invention and methods of immunizing animals against pesudorabies virus disease. The invention further provides a method for distinguishing an animal vaccinated with a vaccine of the present invention from an animal infected with a naturally-occuring pseudorabies virus.


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