The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 1991

Filed:

Jun. 14, 1990
Applicant:
Inventors:

George Kuo, San Francisco, CA (US);

Frank Masiarz, San Francisco, CA (US);

Martha Truett, Oakland, CA (US);

Pablo Valenzuela, San Francisco, CA (US);

Mirella E Rasmussen, Copenhagen, DK;

Jennifer M Favaloro, Victoria, AU;

Daniel Caput, San Francisco, CA (US);

Rae L Burke, San Francisco, CA (US);

Carol Pachl, Oakland, CA (US);

Assignee:

Chiron Corporation, Emeryville, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12P / ; C07H / ;
U.S. Cl.
CPC ...
435 696 ; 435 691 ; 4351723 ; 4352523 ; 43525233 ; 4352402 ; 4353201 ; 435 91 ; 536 27 ; 935 11 ; 935 27 ; 935 29 ; 935 56 ; 935 60 ; 935 70 ; 935 73 ; 935 32 ;
Abstract

Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger RNA, cDNA and/or chromosomal DNA encoding for Factor VIIIC. The Factor VIIIC gene in its entirety, a fragment thereof, or a cDNA is then used for expression of Factor VIIIC in a host. The bacteriophage .lambda.FVIII23D containing the 14.43kb EcoRI fragment was deposited at the A.T.C.C. on Jan. 4, 1984 and given Accession No. 40094. Also, the vector pSVF8-200 was deposited at the A.T.C.C. on July 17, 1985 and given Accession No. 40190.


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