The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 1991
Filed:
May. 10, 1989
Applicant:
Inventors:
Lars J Knutsen, Vedbaek, DK;
Knud E Andersen, Bagsvaerd, DK;
Anker S Jorgensen, Copenhagen, DK;
Ursula Sonnewald, Ballerup, DK;
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514326 ; 546214 ; 546212 ; 546221 ; 546225 ; 546227 ; 549474 ; 549476 ; 549481 ; 549484 ; 549488 ; 549 61 ; 549 62 ; 549 63 ; 549 65 ; 549 68 ; 549 75 ; 548527 ; 548517 ; 514461 ; 514471 ; 514473 ; 514438 ; 514444 ; 514445 ; 514446 ; 514447 ; 514326 ; 514327 ; 514330 ; 514315 ; 514422 ;
Abstract
Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA reuptake from the synaptic cleft.