Aminoglycoside composition having substantially reduced nephrotoxicity

Abstract

This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.4 group that may optionally be present stands for a hydrogen atom or an aliphatic hydrocarbon group R.sub.7 with up to 6 carbon atoms, whose carbon chain may be interrupted by up to 2 oxygen atoms or may be substituted with an oxo group or up to two hydroxyl groups R.sub.5 is an alkyl group having 1 to 4 carbon atoms; and (c) a suitable mixture of the foregoing.