The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 1991
Filed:
Oct. 09, 1990
Applicant:
Inventors:
Mark S Rienstra, Lansdale, PA (US);
Edgar M Scattergood, Lansdale, PA (US);
Robert D Sitrin, Lafayette Hill, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12P / ; C12R / ;
U.S. Cl.
CPC ...
435101 ; 210601 ; 210616 ; 210631 ; 424 88 ; 424 92 ; 435170 ; 435262 ; 435280 ; 435800 ; 435803 ; 435851 ; 536-11 ;
Abstract
A process for removing endotoxin from Gram-negative polysaccharides such as polyribosylribitol phosphate by solubilizing polysaccharide-containing powder derived from Gram-negative bacteria fermentation broth to provide a divalent counter ion for endotoxin and adding alcohol incrementally to induce lipopolysaccharide precipition, and mixing material resulting from the alcohol addition with a nonionic resin, a detergent and a chelating agent.