The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 1991
Filed:
Aug. 04, 1988
Ryuji Nojiri, Aichi, JP;
Yoshihiro Hayakawa, Ichinomiya, JP;
Mamoru Uchiyama, Kawasaki, JP;
Hisatoyo Kato, Ohbu, JP;
Yasuyoshi Chino, Tokyo, JP;
Shinichiro Tahara, Yokohama, JP;
Nippon Zeon Co., Ltd., Tokyo, JP;
Abstract
Phosphoramidite compounds of the general formula ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydroxyl group having a protective group, or the group --OR.sub.4, R.sub.3 represents a hydrogen atom, a hydroxyl group having a protective group, or the group --OR.sub.4, R.sub.4 represents the group ##STR2## X represents a secondary amino group, R.sub.5 represents an allylic residue or a protective group capable of being split off by beta-cleavage, and B.sup.AOC represents a nucleoside base residue in which the amino or imino group is protected with an allyloxycarbonyl-type residue, with the proviso that only one of R.sub.1, R.sub.2 and R.sub.3 represents the group--OR.sub.4. The compounds can be produced by reacting a nucleoside represented by the general formula ##STR3## wherein each of R.sub.1 ' and R.sub.2 ' represents a hydroxyl group which may have a protective group, R.sub.3 ' represents a hydrogen atom, or a hydroxyl group which may have a protective group, and B.sup.AOC is as defined, with the proviso that only one of R.sub.1 ', R.sub.2 'and R.sub.3 ' is a hydroxyl group, with a phosphoramide compound represented by the general formula ##STR4## wherein X and R.sub.5 are as defined, and Y represents a secondary amino group or a halogen atom.