The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 1991
Filed:
Aug. 29, 1988
Applicant:
Inventors:
Atsuhiko Machida, Kanagawa, JP;
Tetsuo Nakamura, Tokyo, JP;
Assignee:
Institute of Immunology Co., Ltd., Koraku, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
424 89 ; 424 88 ; 424 858 ; 530326 ; 530300 ; 514-2 ; 514 13 ;
Abstract
A polypetide vaccine is disclosed with the amino acid sequence of Asp-Pro-Arg-Val-Arg-Gly-Leu-Try-Phe-Pro-Ala-Gly-Gly-Ser-Ser-Ser-Gly-Thr-Va l that bears the receptor for polymerized human serum albumin capable of raising antibodies to inhibit the access and entry of hepatitis B virus (HBV) to hepatocytes. The polypeptide vaccine is also shown in which the 9th amino acid residue (Phe) is replaced by leucine. In addition, there is disclosed hepatitis B polypeptide vaccine P31 which is capable of raising antibodies to block the attachment of HBV to hepatocytes.