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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5015745 B1

PDFFull Text
Date of Patent:
May. 14, 1991

Filed:

Feb. 06, 1989

Process for the preparation of 4-demethoxydaunomycinone, the aglycone of

Applicant:
Inventors:

Silvia De Bernardinis, Milan, IT;

Walter Cabri, Limbiate, IT;

Tiziano Martinengo, Carpignano Sesia, IT;

Franco Francalanci, Novara, IT;

Assignee:

Farmitalia Carlo Erba S.r.l., Milan, IT;

Attorney:

Oblon, Spivak, McClelland, Maier & Neustadt

Primary Examiner:

Richard L Raymond

Assistant Examiner:

Raymond Covington

Int. Cl.
CPC ...
C07C / ; C07C / ;
U.S. Cl.
CPC ...
552206 ; 552201 ;
Abstract

4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyl-daunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound with an amine, removing the amino protecting group from the resultant 4-demethyl-4-(protected amino)-13-dioxolanyl-daunomycinone, diazotizing the thus-freed 4-amino group and reducing under mild conditions the resulting diazonium compound.

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De Bernardinis, Silvia. (1991). Process for the preparation of 4-demethoxydaunomycinone, the aglycone of (U.S. Patent No. 5015745). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5015745

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