The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 1991
Filed:
Jun. 07, 1990
Gary L Olson, Westfield, NJ (US);
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
[(5-oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl-lower alkyl; R.sub.2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, ##STR2## wherein R.sub.5 and R.sub.6 are hydrogen, lower alkyl or aryl-lower alkyl; R.sub.3 and R.sub.4, independently, are hydrogen, lower alkyl, or aryl-lower alkyl; and enantiomers, diastereomers, and racemates thereof, and, when R.sub.2 is ##STR3## pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age-associated memory impairment.