The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 1991
Filed:
May. 08, 1989
Applicant:
Inventors:
Karnail Atwal, Newtown, PA (US);
John R McCullough, Newtown, PA (US);
Gary J Grover, Stockton, NJ (US);
Assignee:
E. R. Squibb & Sons, Inc., Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
5142278 ; 5142358 ; 514255 ; 514315 ; 514307 ; 514609 ; 544 59 ; 544106 ; 544388 ; 546153 ; 546189 ; 558419 ; 564230 ;
Abstract
Novel compounds of the formula ##STR1## and tautomers thereof, wherein at least one of R.sub.2, R.sub.3 and R.sub.4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents. Advantageously, the compounds of the present invention have shown less cardiac effects than known potassium channel activators. Also disclosed is a process for preparing these and other compounds.