The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 1991
Filed:
Mar. 22, 1990
Applicant:
Inventors:
Arthur D Levinson, Hillsborough, CA (US);
Diane Pennica, Burlingame, CA (US);
William J Kohr, San Mateo, CA (US);
Gordon A Vehar, San Carlos, CA (US);
David V Goeddel, Hillsborough, CA (US);
Elizabeth M Yelverton, Seattle, WA (US);
Christian C Simonsen, Saratoga, CA (US);
Assignee:
Genentech, Inc., San Francisco, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 692 ; 435 91 ; 4351723 ; 4352402 ; 4353201 ;
Abstract
A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.