The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 1991
Filed:
Nov. 05, 1987
Antonia Jekkel nee Bokany, Budapest, HU;
Karoly Albrecht, Budapest, HU;
Gabor Ambrus, Budapest, HU;
Tibor Lang, Budapest, HU;
Istvan M Szabo, Budapest, HU;
Eva Ilkoy, Budapest, HU;
Kalman Konczol, Budapest, HU;
Imre Moravcsik, Budapest, HU;
Gabor Hantos, Budapest, HU;
Emilia Simonovits, Budapest, HU;
Zsuzsanna Lengyel nee Szemenyei, Budapest, HU;
Zsuzesanna Vida, Budapest, HU;
Eva Csajagi, Pecs, HU;
Richter Gedeon Vegyeszeti Gyar R.T., Budapest, HU;
Abstract
The invention relates to a process for the production of 9.alpha.-hydroxy-4-androstene-3,17-dione from natural sterols of plant or animal origin or from mixtures thereof by the submerged aerobic fermentation of an enzyme-deficient, sterol-de-grading microorganism in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product formed, which comprises transforming the sterol or sterol mixture with the culture of a 1,2-steroid-dehydrogenase deficient strain of new Mycobacterium roseum species which is able to degrade the side-chain of natural sterols, preferably with Mycobacterium roseum sp. nov. 1108/1 deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM B (P) 000339, and by isolating and purifying the 9.alpha.-hydroxy-4-androstene-3,17-dione obtained.