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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5004686 B1

PDFFull Text
Date of Patent:
Apr. 02, 1991

Filed:

Jan. 04, 1988

Process for producing human epidermal growth factor and analogs thereof

Applicant:
Inventors:

Charles M Cohen, Medway, MA (US);

Roberto Crea, Boston, MA (US);

Assignee:

Creative Biomolecules, Inc., Hopkinton, MA (US);

Attorney:

Lahive & Cockfield

Primary Examiner:

Robin L Teskin

Assistant Examiner:

Richard C Peet

Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12P / ;
U.S. Cl.
CPC ...
435 691 ; 435 697 ; 435 91 ; 435701 ; 435 711 ; 435170 ; 4351721 ; 4351723 ; 435212 ; 4352523 ; 43525233 ; 4353201 ; 435844 ; 536 27 ; 935 10 ; 935 22 ; 935 23 ; 935 24 ; 935 47 ; 935 48 ; 935 49 ; 935 51 ; 935 59 ; 935 60 ; 935 72 ; 935 73 ;
Abstract

Disclosed is a process for producing a fusion protein of epidermal growth factor (EGF) attached through a Glu-residue, treatment of the fusion protein with a Staphylococcus aureus protease specific for cleaving peptides at a Glu-linkage thereby producing large amounts of the 53 amino acid EGF sequence. The treatment conditions optimize production of large amounts of the 53 amino acid sequence relative to the 51 amino acid sequence minus the 52 Leu and 53 Arg residues and take full advantage of the selectivity of the protease.

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Cohen, Charles. (1991). Process for producing human epidermal growth factor and analogs thereof (U.S. Patent No. 5004686). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5004686

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