The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 1991
Filed:
Apr. 21, 1988
Philip E Auron, Framingham, MA (US);
Andrew C Webb, Wellesley, MA (US);
Lee Gehrke, Framingham, MA (US);
Charles A Dinarello, Boston, MA (US);
Lanny J Rosenwasser, Weston, MA (US);
Alexander Rich, Cambridge, MA (US);
Sheldon M Wolff, Wellesley, MA (US);
New England Medical Center, Boston, MA (US);
Tufts College, Boston, MA (US);
Wellesley College, Wellesley, MA (US);
MIT, Cambridge, MA (US);
Abstract
The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.