The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 05, 1991

Filed:

Mar. 10, 1989
Applicant:
Inventors:

Horst Pauling, Bottmingen, CH;

Christof Wehrli, Witterswil, CH;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
549315 ; 549317 ;
Abstract

A process for the manufacture of 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid by esterifying the ascorbic acid with an aliphatic C.sub.2-20 -carboxylic acid halide in the presence of a N,N-dialkyl-alkanecarboxylic acid amide, of a cyclic amide of the 1-methyl-2-pyrrolidone type, of a tetraalkylcarbamide such as tetramethylurea, of a cyclic carbamide of the 1,3-dimethyl-2-imidazolidinone type or of a phosphoric acid triamide of the hexamethylphosphoric acid triamide type. The 6-ascorbyl linolate which can be manufactured in this manner is novel and is likewise an object of the present invention. The thus-manufacturable 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid are important alternative application forms of L-ascorbic acid (vitamin C).


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