The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 1991
Filed:
Jun. 22, 1987
Applicant:
Inventors:
Junichi Yamagishi, Nara, JP;
Hitoshi Kawashima, Osaka, JP;
Ryuji Furuta, Shiga, JP;
Hirotada Kotani, Osaka, JP;
Katuhisa Nakata, Nara, JP;
Assignee:
Dainippon Pharmaceutical Co., Ltd., Osaka, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
435 695 ; 435 691 ; 4351723 ; 4353201 ; 4352523 ; 43525233 ; 935 10 ; 536 27 ; 530350 ; 530351 ;
Abstract
A human TNF polypeptide mutant having an amino acid sequence of modified human TNF polypeptide, a DNA having a base sequence encoding the above human TNF polypeptide mutant and a method of producing the above human TNF polypeptide mutant by culturing a host transformed with a vector having inserted therein the above DNA. The above human TNF polypeptide mutant is soluble and has antitumor activity.