The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 1991
Filed:
Feb. 08, 1989
Loui J Silvestri, Miramar, FL (US);
H Ruth Pyle, Ft. Lauderdale, FL (US);
BioSearch, Inc., Pembroke Pines, FL (US);
Abstract
A multiphasic sustained release injectable delivery system is provided, as well as a method for treating humans and other mammals with that multiphasic sustained release system. The multiphasic sustained release system comprises prolonged, controlled delivery of microencapsulated allergen extract comprising allergen extract encapsulated in microcapsules of bioerodible encapsulating polymer, which permits a subtained, multiphasic release of said allergen extract, including (i) a first portion of allergen extract that upon injection is capable of being released from said microcapsules of bioerodible encapsulating polymer in a manner whereby only a relatively small amount of said allergen extract is released during said first phase, whereby initial allergenicity is minimized due to said first portion producing a mild local reaction similar to that normally observed with low doses of conventional allergen administration; and (ii) secondary portions of allergen extract that provide a substantially higher level of allergen extract in doses which could provoke a serious reaction in the patient, but for the prior release of said first portion.