The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 1991
Filed:
Sep. 26, 1988
Applicant:
Inventors:
Tomoh Masaki, Tsukuba, JP;
Katsutoshi Goto, Tsukuba, JP;
Sadao Kimura, Tsukuba, JP;
Youji Mitsui, Chiba, JP;
Yoshio Yazaki, Tokyo, JP;
Masashi Yanagisawa, Tsukuba, JP;
Hiroki Kurihara, Tokyo, JP;
Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
530326 ; 435 703 ; 514 13 ;
Abstract
Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond. In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium. The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.