The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 1990
Filed:
Aug. 31, 1987
Wylie W Vale, Jr, La Jolla, CA (US);
Jean E Rivier, La Jolla, CA (US);
Richard A McClintock, San Diego, CA (US);
Anne Corrigan, San Diego, CA (US);
Joan Vaughan, San Diego, CA (US);
Joachim Spiess, Encinitas, CA (US);
Nicholas C Ling, San Diego, CA (US);
Shao-Yao Ying, San Diego, CA (US);
Frederick S Esch, Foster City, CA (US);
Roger C Guillemin, La Jolla, CA (US);
The Salk Institute for Biological Studies, San Diego, CA (US);
Abstract
A 28,000-dalton protein with FSH-releasing activity is isolated from porcine follicular fluid in a multi-step procedure including gel filtration, ion exchange chromatography and several reverse-phase high-performance liquid chromatography steps. The 28 kD protein promotes secretion of FSH, but not of LH, in a rat anterior pituitary monolayer culture system, exhibiting an EC.sub.50 of 0.5 ng/ml. These peptides are dimers of inhibin .beta.-chains of mammals, and homodimers or heterodimers of the .beta..sub.A and .beta..sub.B chains are biologically active to regulate fertility of various mammalian species, including humans.