The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 1990
Filed:
Jun. 28, 1989
Yoshitaka Nagai, Tokyo, JP;
Shohei Shibayama, Tokorozawa, JP;
Masaaki Numata, Kawagoe, JP;
Shoji Yoshimura, Iruma, JP;
Makoto Tanaka, Koshigaya, JP;
Masayoshi Ito, Kunitachi, JP;
Akira Awaya, Yokohama, JP;
Hisashi Kobayashi, Mobara, JP;
Hayao Abe, Mobara, JP;
Yusaku Ishizuka, Yokohama, JP;
Tomoya Ogawa, Musashino, JP;
Mect Corporation, Tokyo, JP;
Mitsui Toatsu Chemical, Inc., Tokyo, JP;
Abstract
A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.