The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 1990
Filed:
Dec. 11, 1987
Applicant:
Inventor:
Will Bloch, El Cerrito, CA (US);
Assignee:
Cetus Corportion, Emeryville, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07K / ;
U.S. Cl.
CPC ...
530391 ; 530370 ; 530377 ; 530387 ; 530388 ; 530390 ; 530402 ; 530403 ; 530404 ; 530405 ; 530406 ; 530408 ; 530409 ; 530410 ; 530411 ; 424 8591 ; 514885 ;
Abstract
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD.sup.+ -independent ribotoxins. The methods are useful for preparing therapeutic agents containing these ribotoxins or their A polypeptide components. This separation method has been applied in particular to preparing hybrid toxins containing ricin toxins, both for purifying the resulting products and also for separating the components intended to be used in the preparation of these end products. In addition, a novel ricin isotoxin prepared using the method of the invention is disclosed.