The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 1990
Filed:
Feb. 07, 1985
Applicant:
Inventors:
David F Mark, Danville, CA (US);
Leo S Lin, Fremont, CA (US);
Shi-da Yu Lu, Oakland, CA (US);
Alice M Wang, Walnut Creek, CA (US);
Assignee:
Cetus Corporation, Emeryville, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12P / ;
U.S. Cl.
CPC ...
435 691 ; 530350 ; 530351 ; 530324 ; 530333 ; 4351723 ; 435320 ; 4352523 ; 43525233 ; 435 91 ; 536 27 ; 514-2 ; 514-8 ; 514 12 ; 424 852 ; 424 856 ;
Abstract
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.