The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 1990
Filed:
May. 04, 1989
Sigeru Torii, Okayama, JP;
Hideo Tanaka, Okayama, JP;
Masatoshi Taniguchi, Suita, JP;
Michio Sasaoka, Tokushima, JP;
Norio Saito, Tokushima, JP;
Takashi Shiroi, Tokushima, JP;
Shigemitsu Nagao, Mobara, JP;
Ryo Kikuchi, Tokushima, JP;
Yutaka Kameyama, Tokushima, JP;
Otsuka Kagaku Kabushiki Kaisha, Osaka, JP;
Abstract
Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R.sup.1 is amino or substituted amino and R.sup.2 is a carboxy-protecting group comprising reacting a cephem of the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X is halogen with lead metal while maintaining the pH of the reaction system at about 0.1 to 8. The cephem (I) may be reacted with a catalytic amount of lead metal or a lead compound in the presence of a metal having a greater ionization tendency than lead.