The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 1990
Filed:
Aug. 19, 1988
Applicant:
Inventors:
Robert M Parkhurst, Redwood City, NV (US);
Ronald S Pardini, Reno, NV (US);
Assignee:
Chemex Pharmaceuticals, Inc., Denver, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
568651 ; 568637 ; 568644 ; 568646 ; 568648 ; 568650 ; 568717 ; 568721 ; 568729 ; 568808 ; 568811 ;
Abstract
A grignard synthesis of pharmacologically active 1,4-bis(dihydroxyphenyl)butane and analogs, as well as novel intermediates, is provided, comprising preparing a grignard reagent preferably, a 3,4-dialkoxyphenyl propyl magnesium bromide, which may be reacted with carbonyl compounds to form intermediates of desired end products, said carbonyl compounds preferably being 3,4-dialkoxybenzaldehydes. The resulting alcohol is converted to a corresponding ether or siloxy compound, at the carbonyl site. The oxy-substituent is cleaved off; and the benzene ring or rings dealkylated to leave hydroxy substituents on the rings.