The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 07, 1990

Filed:

Nov. 23, 1988
Applicant:
Inventors:

Gilbert Lavielle, La Celle St-Cloud, FR;

Patrick Hautefaye, Sevron Brie Comte Robert, FR;

Claude Cudennec, La Celle St-Cloud, FR;

Assignee:

Adir et Cie, Neuilly-sur-Seine, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07F / ;
U.S. Cl.
CPC ...
514 81 ; 540478 ;
Abstract

The invention relates to N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkylene radical containing from 1 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and capable of bearing a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidzolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,


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