The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 1990
Filed:
Sep. 17, 1987
Applicant:
Inventors:
Wen-Hwa Lee, San Diego, CA (US);
Eva Y Lee, San Diego, CA (US);
Assignee:
The Regents of the University of California, Berkeley, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; G01N / ; G01N / ; G01N / ;
U.S. Cl.
CPC ...
435-6 ; 435-7 ; 435 29 ; 436 64 ; 436503 ; 436506 ; 436544 ; 436548 ; 436813 ; 530352 ; 530387 ; 530828 ; 935-1 ; 935-6 ; 935 19 ; 935110 ;
Abstract
This invention relates in general to a phosphoprotein product of the retinoblastoma susceptibility gene. In particular, this invention relates to a phosphoprotein ppRB.sup.110 primarily located in the cell nucleus which has a DNA binding activity. The invention also relates to the amino acid sequence of the phosphoprotein and to the specific purified anti-retinoblastoma phosphoprotein antibody. The invention further relates to a method of diagnosing retinoblastoma and other retinoblastoma gene involved cancers, treating such kind of cancers and regulating the oncogenicity of other genes.