The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 03, 1990

Filed:

Jun. 09, 1988
Applicant:
Inventors:

Nigel Phillips, Pointe Claire, CA;

Francoise Audibert, Neuilly Sur Seine, FR;

Jean-Marie Bernard, Fontenay Le Fleury, FR;

Louis Chedid, Paris, FR;

Pierre Lefrancier, Gif S/Yvette, FR;

Michel Level, Paris, FR;

Monique Parant, Paris, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
514-8 ; 530322 ; 536 53 ;
Abstract

The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.


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