The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 1990
Filed:
Mar. 10, 1989
Boehringer Mannheim GmbH, Mannheim, DE;
Abstract
The present invention provides compounds of the general formula: ##STR1## wherein R.sub.1 is a straight-chained or branched C.sub.1 -C.sub.12 -alkyl radical which can be substituted by a phenyl, naphthyl or C.sub.3 -C.sub.7 -cycloalkyl radical, a straight-chained or branched C.sub.2 -C.sub.12 -alkenyl radical which can be substituted by a C.sub.3 -C.sub.7 -cycloalkyl, phenyl or naphthyl radical, a C.sub.3 -C.sub.7 -cycloalkyl radical or an unsubstituted or mono- or polysubstituted mono- or bicyclic aromatic radical, in which the substituents can be halogen atoms, carboxyl groups or C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkoxycarbonyl radicals, R.sub.2 and R.sub.3, which can be the same or different, are straight-chained, branched, saturated or unsaturated C.sub.1 -C.sub.6 -alkyl radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and can possibly be substituted by a C.sub.1 -C.sub.6 -alkyl radical, one or more C.sub.1 -C.sub.6 -alkoxy radicals, one or more hydroxyl groups or by an oxygen atom, X is a methylene radical, an oxygen or sulphur atom, a sulphoxide or sulphonyl group or an .dbd.NR.sub.6 group, in which R.sub.6 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl or aralkyl radical, n is 0, 1 or 2, k is 0, 1, 2 or 3, R.sub.4 is a halogen atom, a hydroxyl group or a C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or aralkoxy radical or, when k is 2, is a C.sub.1 -C.sub.2 -alkylenedioxy radical on two adjacent carbon atoms, m is 0, 1, 2 or 3 and R.sub.5 is a halogen atom, a hydroxyl group or a C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy or aralkoxy radical or, when m is 2, is a C.sub.1 -C.sub.2 -alkylenedioxy radical on two adjacent carbon atoms; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.