The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 1990
Filed:
Jun. 21, 1988
Keith Mills, Ware, GB;
Glaxo Group Limited, London, GB;
Abstract
A process is described for the preparation of a compound of formula (1) ##STR1## or a salt thereof, which comprises reacting a compound of formula (2) ##STR2## (where A is a displaceable atom or group and R is a hydrogen atom or a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents a phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR'.sub.3 (where R' is an alkyl or aryl group) provided that when A is --B(OH).sub.2 X can only represent a conventional leaving group.