The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 1990
Filed:
Jul. 16, 1987
David B Soll, Rydal, PA (US);
Thomsen J Hansen, Havertown, PA (US);
Ihab Kamel, Drexel Hill, PA (US);
Ophthalmic Research Corporation, Philadelphia, PA (US);
Drexel University, Philadelphia, PA (US);
Abstract
A conjugated cytotoxin is provided for preventing posterior lens capsule opacification (after-cataract) after extracapsular extraction. Preferably, the mitotic inhibitor of lens epithelial cells comprises a conjugate containing methotrexate which is covalently linked to an antibody, such as anticollagen, in approximately a molar ratio of 1:1 to 10:1. The mitotic conjugate may be instilled in the anterior or posterior chamber of the eye, preferably immediately after the lens has been removed, or coated onto an intraocular lens prior to insertion onto the posterior lens capsule. Similar conjugates may be attached to other artificial materials in the body to fight fibroblast proliferation.