The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 1990
Filed:
Jun. 09, 1988
Wojciech J Stec, Lodz, PL;
Czeslaw Radzikowski, Wroclaw, PL;
Wieslaw Szelejewski, Warsaw, PL;
Ryszard Kinas, Lodz, PL;
Konrad Misiura, Lodz, PL;
Grzegorz Grynkiewicz, Warsaw, PL;
Jacek Grodner, Warsaw, PL;
Halina Kusnierczyk, Wroclaw, PL;
Andrzej Kutner, Warsaw, PL;
Slawomira Pilichowska, Lodz, PL;
Instytut Przemyslu Farmaceutycznego, all of, PL;
Centrum Baden Molekularnych i Makromolekularnych -PAN, all of, PL;
Instytut Immunologii i Terapii Doswiadczalnej -PAN, all of, PL;
Abstract
Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate. Derivatives that are prepared by the procedure described here demonstrate antitumor activity.