The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 16, 1990

Filed:

Oct. 11, 1988
Applicant:
Inventors:

Frederick J Brown, Crewe, GB;

Victor G Matassa, Chadds Ford, PA (US);

Assignee:

ICI Americas Inc., Wilmington, DE (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514414 ; 5142352 ; 5142282 ; 514415 ; 514419 ; 514255 ; 514323 ; 514316 ; 514318 ; 514381 ; 514339 ; 544 585 ; 544121 ; 544129 ; 544143 ; 544360 ; 544364 ; 544373 ; 546273 ; 546187 ; 546201 ; 546194 ; 548251 ; 548253 ; 548494 ; 548503 ; 548468 ;
Abstract

This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N--CH.dbd.C<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.


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