The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 1989
Filed:
Mar. 26, 1987
Eric K Gustafson, Palo Alto, CA (US);
Rick Trebino, Livermore, CA (US);
John Lee, Cupertino, CA (US);
Yellowstone Diagnostics Corporation, Sunnyvale, CA (US);
Abstract
An improved binding assay plate having greatly reduced non-specific binding with proteinaceous reagents comprising a polysilicon surface having a binding reagent adhered thereto, the surface having a coating adsorbed thereon of a proteinaceous non-specific binding inhibitor. This binding assay product is prepared by adhering binding reagent to a polysilicon surface and then treating the surface with the proteinaceous non-specific binding inhibitor. The binding assay method comprises the steps of contacting the polysilicion surface having a primary binding reagent and non-specific binding inhibitor adhered to the surface thereof with a solution containing an analyte with which the primary binding reagent specifically binds for a time sufficient to permit conjugation of analyte with the primary binding reagent and determining the analyte bound to the polysilicon surface. The plate is suitable for both sandwich and competition immunoassays. The reduction of non-specific binding produces a substantial increase in sensitivity.