The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 1989
Filed:
Dec. 01, 1987
Applicant:
Inventors:
Michael J Broadhurst, Royston, GB;
Balraj K Handa, Welwyn Garden City, GB;
William H Johnson, Hitchin, GB;
Geoffrey Lawton, Hitchin, GB;
Peter J Machin, London, GB;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07F / ;
U.S. Cl.
CPC ...
514 78 ; 514 86 ; 514 89 ; 514 91 ; 514 93 ; 514 92 ; 514 94 ; 514119 ; 540463 ; 540487 ; 544 93 ; 544232 ; 548112 ; 548413 ; 562 15 ;
Abstract
The invention relates compounds of the formula ##STR1## wherein R.sup.1 -R.sup.5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase and can be used in the form of medicaments for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis.