The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 1989
Filed:
Mar. 14, 1988
Applicant:
Inventors:
George R Pettit, Paradise Valley, AZ (US);
Yoshiaki Kamano, Tempe, AZ (US);
Assignee:
Arizona Board of Regents, Tempe, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
514250 ; 544230 ;
Abstract
The marine worm Cephalodiscus gilchristi (Hemichordata phylum) from Southeast Africa has been found to contain powerful inhibitors of the murine P388 lymphocytic leukemia, herein denominated 'cephalostatin 1, cephalostatin 2, cephalostatin 3 and cephalostatin 4'. Pharmaceutical preparations containing the substances and methods of use are described. Cephalostatin 1-3 having the following structure: ##STR1## whereas cephalostatin 4 is an oxy- derivative of cephalostatin 2, having oxygen interposed in the 14-15 double bond as shown below: ##STR2##