The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 1989
Filed:
Oct. 02, 1987
Koichi Arai, Urawa, JP;
Hideo Yoshizaki, Sayama, JP;
Kowa Co, Ltd., Nagoya, JP;
Abstract
A human placenta-derived antiocoagulating substance is prepared by homogenizing a human plancenta, subjecting the resulting homogenate to centrifugal separation, extracting the thus-obtained sediment with a chelating agent, and then separating and purifying the extract. The substance has a molecular weight of 73,000.+-.2,000 as measured in reduced and non-reduced states by SDS-polyacrylamide gel electrophoresis. Its isoelectric point ranges from 6.2 to 6.6 as measured by isoelectric column electrophoresis using an ampholyte. It is inactivated by a heat treatment at 50.degree. C. for 30 minutes, is stable in a pH range of 5.5-8.5 (37.degree. C.) and is also stable in plasma at 37.degree. C. for 15 minutes. It can prolong the recalcification time, prothrombin time and activated partial thromboplastic time.