The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 1989

Filed:

May. 25, 1984
Applicant:
Inventors:

Maurice Hofnung, Paris, FR;

Philippe Quillardet, Paris, FR;

David Perrin, Paris, FR;

Olivier Huisman, Paris, FR;

Richard D'Ari, Paris, FR;

Assignee:

Institut Pasteur, Paris, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C12Q / ; C12Q / ; C12Q / ;
U.S. Cl.
CPC ...
435-6 ; 435 18 ; 435 21 ; 435 29 ; 4351721 ; 435849 ; 43525233 ; 935 82 ;
Abstract

A method for the detection of the mutagen effect of a substance or composition by producing culture of a micro-organism harboring a recombinant of a sfi gene and of a gene coding for a dosable enzyme in the presence of said substance or composition and measuring the activity of the dosable enzyme induced under the control of the sfi gene. When the latter is activated due to the mutagen character of said substance or composition, measuring the activity of a distinct enzyme synthesized by the microorganism and coded by a gene not involved in the activation process of the sfi gene and measuring the variation of the ratio of the activity of the abovesaid dosable enzyme to the activity of said distinct enzyme. Then comparing the variation that of the ratio of the activities of the same enzyme in a culture of the same microorganism, but in the absence of the mutagen substance.


Find Patent Forward Citations

Hofnung, Maurice. (1989). Method for detecting the mutagenicity of substances susceptible of (U.S. Patent No. 4849335). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/4849335

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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