The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 1989
Filed:
Jun. 30, 1986
David Farquhar, Houston, TX (US);
Yuqiang Wang, Houston, TX (US);
Board of Regents, University of Texas System, Austin, TX (US);
Abstract
A compound having the structure ##STR1## wherein R is CH.sub.3 or C.sub.2 H.sub.5 1; R.sup.1 is NH.sub.2, NHCH.sub.3, NHC.sub.2 H.sub.5, NHC.sub.2 H.sub.4 Cl, N(CH.sub.3).sub.2, N(C.sub.2 H.sub.5).sub.2, N(C.sub.2 H.sub.4 Cl).sub.2, OCH.sub.3, C.sub.2 H.sub.5, CH.sub.3, or C.sub.2 H.sub.5, and R.sup.2 is N(C.sub.2 H.sub.4 Cl).sub.2 or NH C.sub.2 H.sub.4 Cl. These compounds may be used to eliminate occult leukemic clonogenic cells from bone marrow by contacting the bone marrow with a solution comprising levels of said compound sufficient to eliminate occult leukemic clonogenic cells. Analogously tumor cells in a host or organ of a host may be eliminated by treatment of the host or host's organ with a compound of this description. Compounds of this description are stable aldophosphamide analogs activatable by the action of an esterase and a subsequent E-2 elimination reaction to form acrolein and a phosphoramidic mustard of the formula: ##STR2## wherein R is NH.sub.2, NHCH.sub.3, NHC.sub.2 H.sub.5, NHC.sub.2 H.sub.4 Cl, N(CH.sub.3).sub.2, N(C.sub.2 H.sub.5, N(C.sub.2 H.sub.4 Cl).sub.2, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.3 or C.sub.2 H.sub.5.