The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 1989
Filed:
Jun. 28, 1985
Applicant:
Inventors:
James J Benedict, Norwich, NY (US);
Charles R Degenhardt, Cincinnati, OH (US);
James W Poser, Fairfield, OH (US);
Assignee:
The Procter & Gamble Company, Cincinnati, OH (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07F / ; C07F / ;
U.S. Cl.
CPC ...
424-11 ; 424-9 ; 534 14 ; 2605 / ; 2605 / ; 514108 ; 514-6 ; 530345 ; 530400 ; 530402 ; 530409 ;
Abstract
Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromolecules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.